Protein Details: Neuronal acetylcholine receptor subunit beta-4

Protein ID

ICDB_Pro_0342

Protein Name

Neuronal acetylcholine receptor subunit beta-4

Gene Name

Chrnb4; Acrb4

Organism

Rattus norvegicus (Rat)

Length

495 amino acids

AlphaFoldDB

AF-P12392-F1-model_v4.pdb

Function

After binding acetylcholine; the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.

Sequence

MRGTPLLLVSLFSLLQDGDCRLANAEEKLMDDLLNKTRYNNLIRPATSSSQLISIRLELSLSQLISVNEREQIMTTSIWLKQEWTDYRLAWNSSCYEGVNILRIPAKRVWLPDIVLYNNADGTYEVSVYTNVIVRSNGSIQWLPPAIYKSACKIEVKHFPFDQQNCTLKFRSWTYDHTEIDMVLKSPTAIMDDFTPSGEWDIVALPGRRTVNPQDPSYVDVTYDFIIKRKPLFYTINLIIPCVLITSLAILVFYLPSDCGEKMTLCISVLLALTFFLLLISKIVPPTSLDIPLIGKYLLFTMVLVTFSIVTTVCVLNVHHRSPSTHTMASWVKECFLHKLPTFLFMKRPGLEVSLVRVPHPSQLHLATADTAATSALGPTSPSNLYGSSMYFVNPVPAAPKSAVSSHTAGLPRDARLRSSGRFREDLQEALEGVSFIAQHLESDDRDQSVIEDWKFVAMVVDRLFLWVFVFVCILGTMGLFLPPLFQIHAPSKDS

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

SITE 81: "Key residue that facilitates effective access of the conotoxin BuIA to the channel binding site"; SITE 133: "Key residue for a low dissociation (K(off)) from the conotoxin BuIA"; SITE 141: "Key residue for a low dissociation (K(off)) from the conotoxin BuIA"

Disease

Location

In the brain; it is detected in the medial habenula. In the peripheral nervous system; it is found at least in the adrenal gland.

DOI ID

10.1016/0896-6273(89)90207-9; 10.1016/s0021-9258(19)39588-2; 10.1111/j.1471-4159.1989.tb02553.x; 10.1021/bi0611715

RefSeq

NP_434693.1 [P12392-1]